MRdb | Univariate analysis

Step 1 / 4: Choose an exposure dataset

ThyroidOmics

8 datasets 271,040 individuals

Inflammatory cytokines

41 datasets 8,239 individuals

Blood cells

74 datasets 746,667 individuals

Circulating proteins

91 datasets 14,824 individuals

Plasma lipidome

179 datasets 7,174 individuals

Skin microbiota

290 datasets 597 individuals

Dutch gut microbiota

412 datasets 7,738 individuals

Blood metabolites

486 datasets 7,824 individuals

Immune cells

731 datasets 3,757 individuals

Plasma metabolome

1,400 datasets 8,299 individuals

Plasma proteome

4,907 datasets 35,559 individuals

eQTLGen (cis-eQTLs)

19,126 datasets 31,684 individuals

Step 4 / 4: Perform MR analysis parameter adjustments

Params

Select MR-specific parameters for perform MR analysis.

Exposure

Outcome

P threshold

MR Method

Heterogeneity Method

MR-PRESSO Corrected MR-PRESSO NbDistribution

Heterogeneity test (leaveoneout)

Heterogeneity test method (leaveoneout)

Horizontal pleiotropy test (funnel plot)

Horizontal pleiotropy test single method Horizontal pleiotropy test all method

Horizontal pleiotropy test (forest plot)

Exponentiate

MR db